The green arrow points out the upregulation of signaling molecules, while the red arrow indicates the downregulation of molecular targets. The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity. Is Acetaminophen Beneficial in Patients With Cancer Pain Who - PubMed Evidence synthesis: Globally, PCa is the second most common cancer . Patients and methods: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: a pilot randomised controlled trial. Epub 2014 Mar 31. 2023 Apr 7;8(15):14264-14270. doi: 10.1021/acsomega.3c01673. Int. National Library of Medicine Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer. Note: EGFR, epidermal growth factor receptor; PAK, p-21 activated kinases; c-Met, tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR); CXCR4, C-X-C Motif Chemokine Receptor 4; PTEN, Phosphatase and tensin homolog; Ras, oncogen; Rho, Rac, and Cdc42, RhoA, RhoC, Rho GTPase; RoCK, Rho-associated protein kinases; uPA, Urokinase plasminogen activator; uPAR, Urokinase plasminogen activator receptor; ECM, extracellular matrix; EMT, epithelialmesenchymal transition; CD44, transmembrane glycoprotein also referred to as P-glycoprotein 1; FAK, Focal adhesion kinase; MMPs, Matrix metalloproteinases; EPCAM, Epithelial cell adhesion molecule; ZEB1, Zinc finger E-box-binding homeobox 1; SLUG, Zinc finger protein SNAI2; RECK, Reversion-inducing cysteine-rich protein with kazal motifs; CCL2, C-C motif chemokine ligand 2; MUC1, Mucin 1; ETAR, Endothelin type A receptor; TGF, Transforming growth factor ; Twist, basic helix-loop-helix factors; SDF1, stromal cell-derived factor 1; Snail, Slug, transcription factors of a snail family; TIMPs, Tissue inhibitors of metalloproteinases; PAI, Plasminogen activator inhibitor 1; MTA3, metastasis-associated protein; EMMPRIN, extracellular matrix metalloproteinase inducer; PN-II: protease nexin-II; alpha1-AT, alpha 1-antitrypsin; EPCAM, epithelial cell adhesion molecule; CK19, Cytokeratin 19; CEA, carcinoembryonic antigen; SAA, serum amyloid A; LOX, protein-lysine 6-oxidase; RAC1, Ras-related C3 botulinum toxin substrate1; cdc42, cell division control protein 42 homolog; S-100, S-100 protein; ST6GALNAC5, 2,6-sialyltransferase; AGPTL4, Angiopoietin-like (ANGPTL) protein; OPN, Osteopontin; CXCR4, chemokine receptor 4; EREG, epiregulin; COX-2, Cyclooxygenase-2; TSP, Thrombospondin; CTCs, circulating tumor cells; VCAM-1, Vascular cell adhesion molecule 1; TNC, tenascin C; CTGF, Connective tissue growth factor, NF-B, Nuclear factor kappa-light-chain-enhancer of activated B cells; PTHLH, parathyroid hormone-like hormone. Effect of Hydrogen-Enriched Solvents on the Extraction of Phytochemicals in Propolis. We identify aberrant expression of G-protein-coupled receptor 141 (GPR141) in different breast cancer subtypes that correlate with poor prognosis. Before -, Roy P., Saikia B. doi: 10.1007/s11101-022-09816-1. 2023 Mar 30;28(7):3107. doi: 10.3390/molecules28073107. 2023 Jan 18;11(2):259. doi: 10.3390/biomedicines11020259. Due to the side effects and drug resistance of anticancer drugs, the recent research on cancer . -. Broad targeting of angiogenesis for cancer prevention and therapy. Accessibility Before The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Experimental Evidence for Therapeutic Potentials of Propolis. Chavda VP, Chaudhari AZ, Teli D, Balar P, Vora L. Biomedicines. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. Bethesda, MD 20894, Web Policies Izuta H., Shimazawa M., Tsuruma K., Araki Y., Mishima S., Hara H. Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells. we use NIC-CTC scale for determining mucositis grading. The chemopreventive effect of propolis in several cancer types is mediated by inhibiting tumor growth and induction of apoptosis further, and in another way, it scavenges the reactive oxygen species and stimulates the activity of antioxidant enzymes . Tazawa S., Arai Y., Hotta S., Mitsui T., Nozaki H., Ichihara K. Discovery of a novel diterpene in Brown propolis from the state of parana, Brazil. Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: an experimental and theoretical approach. 2023 May 24;14(5):203-214. doi: 10.5306/wjco.v14.i5.203. In addition, propolis inhibits the interaction of ACE2 and SARS-CoV-2 virus. Orsolic N., Sver L., Terzic S., Bai I. Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity. Anticancer Effects of Propolis Extracts Obtained with the Cold - PubMed Sci. 8600 Rockville Pike Also, the mRNA expression of tissue inhibitor of matrix metalloproteinases (TIMPs) and MT-1 MMPs was decreased in CAPE-treated cells. Antimetastatic effect of propolis and its polyphenolic/flavonoid compounds. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Figure 1 shows the biological properties of propolis and its bioactive components. Chikaraishi Y., Izuta H., Shimazawa M., Mishima S., Hara H. Angiostatic effects of Brazilian green propolis and its chemical constituents. The role and possible mechanisms of action of propolis and its flavonoids in regulation of inflammatory pathways by (i) antioxidative and radical scavenging activities, (ii) regulation of cellular activities of inflammatory cells, (iii) modulation of the enzymes involved in arachidonic acid metabolism (phospholipase A2, cyclooxygenase, and lipoxygenase) and nitric oxide synthase, (iv) modulation of the release of other pro-inflammatory molecules, and (v) transcriptional modulation of proinflammatory genes are shown. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. In another study, CAPE hinders the migratory and invasive ability of NPC cells by reversing the epithelial-mesenchymal transition (EMT) pathway by modulating the EMT marker protein expression. . The CAPE (130M) suppressed the growth of human multiple myeloma cells while leaving normal peripheral blood B cells unaffected. Exposure to ethanolic Chinese propolis extract (EECP) significantly increased annexin A7 expression, ROS, NF-B, and p65 expressions and dramatically altered the potential of mitochondrial membrane [86]. The propolis is multifaceted, and the chemical composition differs according to bee species, geographical origin, and plants that stimulate the bee's biological activities [26, 27]. Of 1305 articles published, only eight studies were selected; among their principal characteristics was the use of in vitro analysis with cell lines . Depending on the botanical sources and the geographical origin, biological activities of propolis vary. Woo K. J., Jeong Y. J., Park J. W., Kwon T. K. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Overall, the studies have found that propolis and its constituents inhibit cell migration, epithelial-to-mesenchymal transition, and tumor metastasis by regulating several signaling molecules such as growth factors (EGF, VEGF, PDGF, HIF-1, and FGF), EMT markers (vimentin, E-cadherin, -catenin, and Snail), and metastatic-related proteins (MMPs, uPA, and interleukin). Before -, Virchows Arch. The CAPE has the ability to promote apoptosis in breast cancer cell lines (MCF-7 and MDA-MB-231) [86]. Phytochem. This site needs JavaScript to work properly. MeSH The Role of Propolis as a Natural Product with Potential Gastric Cancer Treatment Properties: A Systematic Review. Interrelationship between ROS, oxidative stress, and inflammation-induced immune dysregulation and cancer pathophysiology. Reports from a recent study reveal that CAPE blocks the expression of the MALT1 gene to decrease the cell proliferation, invasion, and tumor growth of prostate carcinoma cells via the p53 and NF-B signaling pathways, and they further verify that CAPE is an effective antitumor agent for human androgen-dependent and androgen-independent prostate carcinoma cells by inhibiting MALT1 expression in vitro and in vivo [80]. CA Cancer J. Clin. Lately, numerous studies have reported that the inhibitor for angiogenesis is evolved to treat cancer by targeting the multiple molecules and signaling pathways, which are regulating the angiogenesis process [106]. Cetin E. O., Salmanoglu D. S., Ozden I., et al. -, BMC Immunol. Furthermore, CAPE exposure caused a disruption of the cell cycle in the S phase in HEp-2 cells by inhibiting the STAT-3/PLK-1 pathway [45]. The .gov means its official. Propolis is a bee-metabolized resinous substance (bee glue) from plant sap and gums. The CAPE treatment showed strong cytotoxic activity on NPC cell lines. doi: 10.3322/caac.21660. Accessibility Propolis and its bioactive compounds induce apoptosis in various cancer cells through extrinsic and intrinsic apoptotic pathways. It also promotes apoptosis in NPC cells by downregulating the expression of antiapoptotic proteins Bcl-xL, elevating the expression of proapoptotic proteins Bax, and generating PARP cleavage [46]. Lima Cavendish R., de Souza Santos J., Belo Neto R., et al. 2021 Jul 24;13(8):2528. doi: 10.3390/nu13082528. Sobocanec S., Sverko V., Balog T., et al. official website and that any information you provide is encrypted Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. The role of propolis and its compounds in the regulation of signaling pathways, MeSH Note: ROS, Reactive oxygen species; NO, Nitric oxide; NF-B, Nuclear factor kappa-light-chain-enhancer of activated B cells; UV, ultraviolet radiation; SOD, Superoxide dismutase; CAT, Catalase; Nrf2, nuclear factor E2-related factor 2; VEGF, Vascular endothelial growth factor; MMPs, Matrix metalloproteinases; GSH, Reduced glutathione; HIF-1, Hypoxia-inducible factor-1; Trx, Thioredoxin; TrxR, thioredoxin reductase. Allergic Inflammation: Effect of Propolis and Its Flavonoids. Pasupuleti V. R., Sammugam L., Ramesh N., Gan S. H., Honey P., Jelly R. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Angiogenesis is regulated via various signaling pathways, which are extremely complex and involve numerous angiogenic mediators. In vitro antiproliferative/cytotoxic activity on cancer cell lines of a cardanol and a cardol enriched from thai. An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms. The CAPE treatment showed the suppressed extracellular signal-regulated kinase (ERK) and Akt phosphorylation and decreased cyclin D expression in 3T3-L1 fibroblast cells [12]. Propolis is a natural resinous substance produced by honeybees from plant-based natural source materials like tree buds, sap flowers, etc., by mixing with saliva secretions. Another study examined the anticancer properties of the CAPE analogue chemical 5A in nasopharyngeal carcinoma (NPC) cells. Brazilian red propolis, a water-insoluble resinous mixture of the saliva of bees (Apis mellifera) and vegetable exudate, mainly from Dalbergia ecastaphyllum (L) Taub, has strong antioxidant activity and has been investigated and proposed as an inhibitor of angiogenesis [34, 115]. 2023 Jan 30;11(2):135. doi: 10.3390/toxics11020135. It is used for the protection from infections, to seal gaps, openings in the hive, and toughen combs, and also, propolis is used to maintain the hive's internal temperature, leveling the beehive surface to protect from abnormal weather and predators [12]. Kimoto T., Koya S., Hino K., et al. Abstract. They discovered that chemical 5A effectively suppressed cell proliferation while having negligible cytotoxicity in normal cells. sharing sensitive information, make sure youre on a federal ; Houston, TX, USA: 2007. pp. Sahinler N., Kaftanoglu O. -, Greenwell M., Rahman P. Medicinal plants: Their use in anticancer treatment. Pharmaceuticals (Basel). Previous preclinical studies have reported that major compounds in the propolis such as flavonoids and polyphenols are responsible for its chemopreventive and anticancer effects [70, 71]. Rev. Molecules. These results add to the current evidence available suggesting not to use acetaminophen as an adjuvant for advanced cancer patients with moderate to severe cancer pain who are on strong opioids. anticancer; apoptosis; caffeic acid phenethyl ester; chrysin; propolis. FOIA Would you like email updates of new search results? Propolis is reported to possess an array of biological properties including anti-inflammatory, antioxidant, anti-cancer, and anti-diabetic as well as cardioprotective, hepatoprotective, renoprotective, and derma protective activities. 2022. Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with walker 256 tumor cells. However, the molecular mechanism via which GPR141 advances breast cancer remains elusive. HHS Vulnerability Disclosure, Help Caffeic acid inhibits human retinal tumor angiogenesis by blocking VEGF expression through STAT-3 [112]. 2022 Oct 8;27(19):6694. doi: 10.3390/molecules27196694. It is used by bees as glue, a general-purpose sealer, and as draught-extruder for beehives. 2022 Sep 9;23(18):10479. doi: 10.3390/ijms231810479. See this image and copyright information in PMC. Curti V., Zaccaria V., Sokeng A. J. T., et al. 2021;40(S1):S15-S25. 2022 Sep 9;23(18):10479. doi: 10.3390/ijms231810479. The influence of propolis and its components on cell proliferation. A number of factors induce the generation of high levels of reactive radicals (ROS), leading to oxidative stress (OS) and OS-induced inflammation. Galangin and apigenin may be responsible for these inhibitory actions [131]. The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. However, a study with tumor cell lineages revealed that different concentrations of red propolis are associated with different profiles of cytotoxicity [117]. Jung and co-workers conducted an extensive study using caffeic acid, in which caffeic acid inhibited the tube formation in HUVEC (human umbilical vein endothelial) cells in 3D culture, and also, this treatment inhibited the angiogenesis of human kidney tumor implanted in nude mice. The information mentioned here is not offered as specific medical advice for any individual and . Overview of the biological properties of propolis and its bioactive components. Propolis: A Wonder Bees Product and Its Pharmacological Potentials Elnakady et al. The Emerging Role of Autophagy as a Target of Environmental Pollutants: An Update on Mechanisms. Clin. The site is secure. Propolis and Their Active Constituents for Chronic Diseases. The CAPE induction of apoptosis in multiple myeloma cells was validated by flow cytometry, with up to 50% apoptotic cells induced by 50M CAPE within 24h by activating the apoptosis executioner enzyme caspase-3 and corresponding cleavage of PARP. Another latest research reported that Turkey originated propolis extract can have antiproliferative, apoptotic, and cell cycle arrest potential against cancer cell lines. However, the commercially existing drugs are only effective against certain types of tumor due to the complexity of cancer, particularly cancer signaling and angiogenesis [107]. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. Suppression of hypoxia-inducible factor-1. Ahangari Z., Naseri M., Vatandoost F. Propolis: chemical composition and its applications in endodontics. Interaction between propolis and its polyphenolic/flavonoid components and the intestinal microbiota. You will find work from respected institutions related to bee propolis in general and also specific types of bee propolis. eCollection 2023 Apr 18. To guarantee consistent quality and effectiveness control of the propolis product, standardization of the chemical composition of propolis extract is required. The .gov means its official. 2016 Nov;40:550-560. doi: 10.1016/j.intimp.2016.10.008. Propolis has been used by humans for many years as a powerful herbal and dietary supplement. The .gov means its official. Structural, Optical, and Electrical Characterization of Biological and Bioactive Propolis Films. However, further clinical studies are needed to validate the ratio of propolis compounds in human subjects and also allergenic reactions to propolis, and its dosage merits require further research. In this review, we summarize the current knowledge related to the the effects of flavonoids and other polyphenolic compounds . A., Silveira M. A. D., Capcha J. M. C., De Jong D. Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: running title: propolis against SARS-CoV-2 infection and COVID-19. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. Ethanolic extract of senna velutina roots: chemical composition, in vitro and in vivo antitumor effects, and B16F10-nex2 melanoma cell death mechanisms. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The aim of this review is to highlight and summarize the molecular targets and anticancer potential of propolis and its active compounds on cell survival, proliferation, metastasis, and apoptosis in cancer cells. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Szliszka E, Zydowicz G, Janoszka B, Dobosz C, Kowalczyk-Ziomek G, Krol W. Int J Oncol. According to a recent research, natural products are becoming increasingly essential in cancer prevention. Chrysin attenuates cell viability of human colorectal cancer cells through autophagy induction unlike 5-fluorouracil/oxaliplatin. nakai extract inhibits proliferation and induces apoptosis in breast cancer cells through Akt/NF-. Apoptosis is a programmed cell death regulated by two different pathways: 1. extrinsic pathway: activated by external factors like TNF- (tumor necrosis factor-), FasL (Fas ligand), and TNF-related apoptosis-inducing ligand (TRAIL); 2. intrinsic or mitochondrial-mediated pathway: this pathway is induced by ROS, which disrupts the mitochondrial membrane potential that leads to activation of proapoptotic proteins (p53, Bax/Bad, and cytochrome c) [84]. Propolis' anticancer mechanisms are diverse, since it operates on a variety of cancer metabolic targets. Ziyad S., Iruela-Arispe M. L. Molecular mechanisms of tumor angiogenesis. Clin Exp Reprod Med. The main chemical groups responsible for the various pharmacological properties and health-related uses of propolis. Here, starting with our current understanding of PDAC characteristics, including precursor lesions, progression models, tumor microenvironment, and therapeutic advancements, we describe how proteomics contributes to the functional and clinical exploration of PDAC, providing insights into PDAC carcinogenesis, progression, and chemoresistance. PROPOLIS & CANCER - Propolis Science Frion-Herrera Y., Diaz-Garcia A., Ruiz-Fuentes J., Rodriguez-Sanchez H., Sforcin J. M. The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation. -, Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Ethanolic extract of Brazilian green propolis sensitizes - PubMed Molecular and Cellular Mechanisms of Propolis and Its - PubMed Propolis also reduced radiotherapy-induced reductions in total antioxidant capacity, hemoglobin (Hb) concentration, white blood cells (WBCs), and platelet counts. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. Orsolic N., Benkovic V., Lisicic D., Dikic D., Erhardt J., Horvat Kneevi A. This figure was created by, Proposed model illustrating the effect of propolis on cell proliferation and the cell cycle of cancer cells. An official website of the United States government. Chavda VP, Chaudhari AZ, Teli D, Balar P, Vora L. Biomedicines. Ren X., Liu J., Hu L., Liu Q., Wang D., Ning X. Caffeic acid phenethyl ester inhibits the proliferation of HEp2 cells by regulating stat3/plk1 pathway and inducing S phase arrest. The association between the antiangiogenic and antioxidant effects of propolis was evaluated in vitro using endothelial cells; unsurprisingly, the most antiangiogenic compounds also had antioxidant properties [114]. All of these studies have reported the anticancer activities of propolis and its well-known active components including caffeic acid, CAPE, chrysin, and artepillin C. Most in vitro and in vivo studies demonstrated that propolis targets various growth factor signaling, thereby it inhibits cell proliferation, cell cycle progression, cancer cell migration, and invasion and induces apoptosis in cancer cells. Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo. Antiproliferative and cytotoxic activity of CP against MDA . Oroli N., Bai I. Doi K., Fujioka M., Sokuza Y., et al. The Potential Use of Propolis as an Adjunctive Therapy in Breast Renal carcinogenesis induced by ferric nitrilotriacetate in mice, and protection from it by Brazilian propolis and artepillin C. Kimoto T., Koya-Miyata S., Hino K., et al. 2017;131:17811799. This site needs JavaScript to work properly. Drug Metab. Characterization and biological evaluation of propolis from Poland. Ethanol-extracted cameroonian propolis: antiproliferative effects and potential mechanism of action in prostate cancer. Chem. Brazilian and Croatian propolis (50g/ml)-treated cells showed a significantly increased apoptotic percentage of MCF-7 and HeLa cells as compared to the control and V19 normal fibroblasts. Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms. 2019;5:e01978. Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. 2001 Mar;438(3):259-70 Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With -Cyclodextrin. All of this evidence suggests that CAPE induces apoptosis in human multiple myeloma cells via oxidative stress [59]. What is propolis? and transmitted securely. Bethesda, MD 20894, Web Policies Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.
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