A Case of Anaphylaxis Caused by Major Royal Jelly Protein 3 of Royal Jelly and Its Cross-Reactivity with Honeycomb. In addition, molecular targeted therapy and immunotherapy are also commonly used for a variety of cancers. The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines. The World Health . Finally, we have summarized previous reports on the suppression of toxicities by RJ in malignancies in Table 1. Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. 2. Kim C., Kim B. Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review. Yoneshiro T., Kaede R., Nagaya K., Aoyama J., Saito M., Okamatsu-Ogura Y., Kimura K., Terao A. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Chen Y.F., Wang K., Zhang Y.Z., Zheng Y.F., Hu F.L. and transmitted securely. RJ is a hypopharyngeal and mandibular glandular secretion of nurse honey bees. Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. Cyclophosphamide is a cytotoxic alkylating agent that it is often used for the treatment of cancer. Hormone therapy, chemotherapy and radiotherapy, Ameliorated toxicity in a double-blind randomized study, Histopathologic findings in the testes were partially reversed, Improved serum levels of testosterone and sperm parameters. Zargar H.R., Hemmati A.A., Ghafourian M., Arzi A., Rezaie A., Javad-Moosavi S.A. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Propolis Abdel-Hafez S.M.N., Rifaai R.A., Abdelzaher W.Y. Royal jelly is a viscous substance secreted by worker bees and constitutes the essential food for queen bees and their larvae. However, the scientists found . In patients with advanced or metastatic tumors, systematic therapies with anti-cancer agents are usually fundamental treatment strategies; however, the anti-cancer effects, including prolongation of survival, of such systematic therapies are not always satisfactory in clinical practice. Silici S., Ekmekcioglu O., Kanbur M., Deniz K. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. Finally, the authors commented that more detailed information on the active substance and physiological properties are important for the clarification of the anti-cancer effects of RJ and we support this opinion. Furthermore, PGE2 is an important modulator for the activities of immune cells, including macrophages, dendritic cells and natural killer cells [34,35,36]. Inflammation and oxidative stress are closely associated with anti-cancer agent-induced toxicities [67,68]. In this section, we have introduced the molecular mechanism for the prevention of such cancer therapy-induced toxicities (Table 2). Their results showed that all patients in the control group experienced grade 3 mucositis, which progressed to grade 4 in one patient at 1 month after treatment but that grade 3 mucositis was observed in only 71.4% of patients in the RJ group. Royal jelly is known as a functional food containing many useful minerals. RJ contains water, sugar, proteins and lipids and approximately 90% of RJ lipids are free fatty acids, containing 812 carbons that are usually either hydroxyl or dicarboxylic forms [21]. Townsend G.F., Morgan J.F., Tolnai S., Hazlett B., Morton H.J., Shuel R.W. However, there are only a few reports of the changes in fibrosis-related factors caused by RJ administration in vivo. In recent years, the consideration of natural products as anti-cancer treatments has grown worldwide [4,5,6]. This study also showed that such cancer cell proliferation was inhibited by RJ in the presence of bisphenol, which has environmental estrogen activity, even though RJ did not affect the proliferation in the absence of bisphenol. In addition, various natural compounds have been reported to be useful to improve the anti-cancer effects of certain chemotherapeutic agents. Effect of Processed Honey and Royal Jelly on Cancer-Related Borawska M.H., Markiewicz-ukowska R., Naliwajko S.K., Moskwa J., Bartosiuk E., Socha K., Surayski A., Kochanowicz J., Mariak Z. Royal jelly supplementation improves lipoprotein metabolism in humans. Majtan J., Kumar P., Majtan T., Walls A.F., Klaudiny J. Cornara L., Biagi M., Xiao J., Burlando B. In contrast, their results also showed that similar cytotoxic efficacy of the combination therapies was not detected in diffuse astrocytoma cells [27]. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial. In fact, CDDP remarkably increased the expression of caspase-3, which is a key mediator of apoptosis, in the kidney and liver of rats. The authors speculated that the small sample size may be the explanation for this difference and suggested that further investigation with a larger sample size should be conducted to confirm this issue. The therapeutic potential of royal jelly in benign prostatic In addition, this study showed that although CP led to marked morphological changes, such as cystic dilatation with lost papillary fold in acini, flattened lining epithelium, wall integrity and apparent rupture of some acini, these changes of pathological features were suppressed by RJ via the modulation of Bax immunoreactivity [51]. There are claims that it offers a range of health benefits, such as easing the. However, a similar significant improvement of kidney function parameters was not found in RJ group. Home News Sport Radio TV Weather Languages [an error occurred while processing this. Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Interestingly, their study also showed that the highest anti-proliferative activity was obtained when RJ and IFN- were applied at the ratio 2:1, in a comparison of the ratios of 1:1 or 1:2 [28]. Chen W., Huang C., Yang C., Ge X., Huang W., Li X., Yang S., Liu S. Danggui sini decoction protected islet endothelial cell survival from hypoxic damage via PI3K/Akt/eNOS pathway. Therapeutic Properties of Bioactive Compounds from Different Honeybee Products. Thus, their results support the role of RJ as an anti-oxidant in response to the oxidative stress caused by a variety of anti-cancer agents. Ohba K., Miyata Y., Watanabe S., Hayashi T., Kanetake H., Kanda S., Sakai H. Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1 - 4 in patients with renal cell carcinoma. Ready to start planning your care? Statements made about products have not been evaluated by the Food and Drug Administration. the contents by NLM or the National Institutes of Health. Chemical Characterization and Biological Properties of Royal Jelly Khoubnasabjafari M., Ansarin K., Jouyban A. They help minimize free radicals, . Royal Jelly Benefits - Dr Sarah Brewer Cancer A study on propolis supplementation for colon cancer prevention in high-risk patients found no benefit, and actually indicated potential negative effects on muscle tissues including heart muscle cells. Thus, in animal models, RJ protects from pro-apoptotic activity and the anti-proliferative effects caused by a variety of anti-cancer agents in several normal tissues. We have also dedicated specific attention to RJ in this review because of following reasons and findings: (1) RJ is special food for queen honeybee in both the larva and adult stages. The influence of royal jelly and human interferon-alpha (HuIFN-N3) on proliferation, glutathione level and lipid peroxidation in human colorectal adenocarcinoma cells in vitro. (2) RJ can modulate inflammation, oxidative stress and vasodilatory activity [8,9,10,11,12]. Abdel-Daim M.M., El-Sayed Y.S., Eldaim M.A., Ibrahim A. Nephroprotective efficacy of ceftriaxone against cisplatin-induced subchronic renal fibrosis in rats. To understand the mechanisms of the beneficial effects of RJ, knowledge of the changes induced at the molecular level by RJ with respect to cell survival, inflammation, oxidative stress and other cancer-related factors is essential. Itatani Y., Kawada K., Sakai Y. according to the Memorial Sloan Kettering Cancer Center. Glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glutathione-S-transferase (GST) are known endogenous anti-oxidants and anti-oxidant parameters [72]; increased levels and activities of these factors were detected in the kidney and the liver of rats treated with CDDP and RJ compared with those administered CDDP alone [47]. Royal jelly swished, then swallowed, along with standard mouthwash therapy improved symptoms of oral mucositis and healing time in patients receiving radiotherapy and chemotherapy(29). Royal jelly suppresses pro-inflammatory cytokines, lowers your risk of cancer, and controls inflammation during treatment. Bethesda, MD 20894, Web Policies Yang Y.C., Chou W.M., Widowati D.A., Lin I.P., Peng C.C. Furthermore, this study suggested that a decrease in prostaglandin E (PGE)-2 might be associated with such anti-cancer effects in addition to immunity-related host resistance [30]. Royal Jelly This will help them manage your care and keep you safe. Federal government websites often end in .gov or .mil. Another small study suggests benefit with topical royal jelly ointment in head and neck cancer patients(30). Therefore, RJ is thought to exert anti-cancer effects on tumor growth and exhibit protective functions against drug-induced toxicities. Royal JellyA Traditional and Natural Remedy for Postmenopausal Zhang S., Shao Q., Geng H., Su S. The effect of royal jelly on the growth of breast cancer in mice. It is consumed as a health food around the world. Nephrotoxicity and hepatotoxicity are the most important of these events [45,46], because they can be fatal to patients with cancer. Nurse bees feed royal jelly to all larvae, which serves as the primary signal for a larva to mature into a queen. For example, in patients with head and neck cancer, a randomized single (physician)-blind trial with an RJ-treated group (n = 7) and a control group (n = 6) was performed to evaluate the clinical utility of RJ for the prevention of oral and esophageal mucositis [59]. Using commercial jelly shipped from China, initial studies from Klein's lab have started to resolve the oligomer structure of MRJP-1 (major royal jelly protein 1). For example, there is a report that among the two protein fractions obtained from the protein extract of RJ precipitated with 30% and 60% ammonium sulfate (called RJP30 and RJP60, respectively), the survival of human cervical cancer cells (HeLa) was inhibited by RJP30 but not by RJP60 [80]. The induction of such changes at the molecular level by RJ are speculated to confer the protective effects of renal function because such pro-fibrotic changes are closely associated with CDDP-induced nephrotoxicity [77]. Other investigators have also shown that RJ reversed TGF- levels in the BALF of rats treated with BLM [43]; unexpectedly, they also found that significant activity was detected in in rats orally administered RJ at 50 and 100 mg/kg/day but not at 25 mg/kg/day. Histopathologic findings and oxidative parameters were partially reversed. Effect of Memo(R), a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment. Briefly, in a mouse model, the oral administration of 10 g/kg RJ showed no acute toxicity [83]. Decreasing the incidence and severity of adverse events induced by anti-cancer therapies is of great importance for the maintenance of the quality of life (QOL) of patients with cancer. Methods In addition, many investigators have given special attention to pharmacotherapy using natural substance as promising future therapeutic options. Royal jelly, which causes epigenetic changes in bee colonies, has the potential to cause a change in cancer cells. Therefore, in this review, we have covered the following five issues: (1) the anti-cancer effects of RJ and its main component, 10-hydroxy-2-decenoic acid; (2) the protective effects of RJ against anti-cancer agent-induced toxicities; (3) the molecular mechanisms of such beneficial effects of RJ; (4) the safety and toxicity of RJ; and (5) the future directions of RJ-based treatment strategies, with a discussion on the limitations of the study of the biological activities of RJ. However, they still need further research and studies the reason why medical experts only suggests them as a form of backup therapy. Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. Regulation of the immune response by prostaglandins. Schmidt H.H., Stocker R., Vollbracht C., Paulsen G., Riley D., Daiber A., Cuadrado A. Antioxidants in Translational Medicine. Honeybees, Apis mellifera, are a source of a variety of precious and valuable natural products with health-promoting bioactive compounds including honey, bee bread, bee venom, bee pollen, propolis, and royal jelly (RJ). It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities. Townsend G.F., Morgan J.F., Hazlett B. Neamatallah T., El-Shitany N.A., Abbas A.T., Ali S.S., Eid B.G. As a Gay Man, I'll Never Be Normal In this study, RJ administration led to a decrease in the malondialdehyde level and an increase in superoxide dismutase, catalase and glutathione-peroxidase activities; in addition, the authors commented that RJ may suppress CDDP-induced sperm toxicity owing to its antioxidant activities. As a library, NLM provides access to scientific literature. The effect of topical application of royal jelly on chemoradiotherapy-induced mucositis in head and neck cancer: a preliminary study. In rats treated by MTX, the plasma MDA levels in the MTX and RJ-treated group were significantly lower than those in the MTX-treated group and the plasma levels of SOD and GSH-Px in the MTX and RJ-treated group were higher than those in MTX-treated group [52]. Royal jelly benefits backed by science Interestingly, it was also shown that RJ reversed the histopathological alterations induced by BLM and increased the anti-fibrotic cytokine, interferon (IFN)-, in BALF that was decreased by BLM [43]. However, RJ treatment decreased such caspase-3 reactivity in the proximal tubules of tissues of the kidney and the liver [47]. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti Briefly, the combination of TMZ with honey, beebread and RJ, exerted stronger cytotoxic activity on human glioblastoma multiforme cells (U87MG) than TMZ alone. Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study. Decreased Risk of Cancer. Protective effects against taxol-induced testicular damage were attributed to improved antioxidant status and E2f1 transcription factor upregulation(31). Royal Jelly: Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies . Preclinical studies suggest royal jelly may reduce blood pressure, cholesterol levels, and inflammation. Challenges in the local delivery of peptides and proteins for oral mucositis management. Thus, we also agree with their opinion that the search for more effective and disease-specific fractions of RJ may be critical for improvements in the anti-cancer effects. In regard to oxidative stress, RJ was shown to exert no significant influence on MDA and GSH levels in the kidney of mice under physiological conditions [66]. In general, RJ is administered orally when used as a supplement and a prophylactic because of simplicity. INTRODUCTION. Karadeniz A., Simsek N., Karakus E., Yildirim S., Kara A., Can I., Kisa F., Emre H., Turkeli M. Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin. It's also called honey bee milk, bee spit, and bee saliva. Various clinical trials on the prevention of mucositis induced by anti-cancer therapies are ongoing [56,57,58]. Honey and royal jelly could become part of the arsenal of weapons against cancer, researchers say. A majority of the country thinks that at least 20 percent of Americans at least one in five of us are gay or lesbian. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. 4. Propolis, and Royal Jelly: . Sobral F., Calhelha R.C., Barros L., Dueas M., Toms A., Santos-Buelga C., Vilas-Boas M., Ferreira I.C. Nakajima Y., Tsuruma K., Shimazawa M., Mishima S., Hara H. Comparison of bee products based on assays of antioxidant capacities. However, the clinical usefulness and anti-cancer effects are often restricted owing to the wide variety of adverse effects observed, such as nausea, neurotoxicity, alopecia and fatigue. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Many reports demonstrated that RJ is useful for protection against anti-cancer agent-induced toxicities, such as mucositis, fibrosis and disorder of the kidney and the liver. Severe anaphylaxis to royal jelly attributed to cefonicid. Samavat H., Kurzer M.S., Sakuramoto A., Hasegawa Y., Sugahara K., Komoda Y., Hasegawa K., Hikasa S., Kurashita M., Sakai J., et al. Royal jelly, organic honey, pollen, propolisand bees waxare all honeybee products containing valuable health nutrients that can fight against cancer. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells. Silici S., Ekmekcioglu O., Eraslan G., Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Whether consuming royal jelly benefits humans is still undetermined, as there haven't been sufficient clinical studies to prove health benefits. BBC NEWS | Health | Honey 'could help fight cancer' The function of RJ may be attributed to its major and unique fatty acid, 10-hydroxy-2-decenoic acid (10-HDA). Does Supplementation with Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients? Royal jelly is substance produced by honeybees to serve as food for the queen bee, helping to make her larger and longer-lived than other bees. 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